Clone REA280 recognizes the CD62 antigen-like family member E (CD62E) antigen, a 115 kDa single-pass type I membrane protein which is also known as E-selectin, endothelial-leukocyte adhesion molecule 1 (ELAM-1), or leukocyte-endothelial cell adhesion molecule 2 (LECAM2). CD62E is a cell adhesion molecule highly expressed only on endothelial cells activated by cytokines. It is not stored in the cell and has to be transcribed, translated, and transported to the cell surface. The production of CD62E is stimulated by the expression of CD62P which is stimulated by tumor necrosis factor α, and it can also be stimulated by interleukin-1 and lipopolysaccharide. CD62E recognizes and binds to sialylated carbohydrates present on the surface proteins of certain leukocytes. CD62E ligands are expressed by neutrophils, monocytes, eosinophils, memory-effector T-like lymphocytes, and natural killer cells. Each of these cell types is found in acute and chronic inflammatory sites in association with expression of CD62E, thus implicating CD62E in the recruitment of these cells to such inflammatory sites.

Additional information: Clone REA280 displays negligible binding to Fc receptors.